Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice
D Ye, M Hoekstra, R Out, I Meurs, JK Kruijt… - Atherosclerosis, 2008 - Elsevier
BACKGROUND: ABC-transporters play an important role in lipid trafficking. Therefore,
hepatic expression patterns of ABC-transporters involved in the regulation of cholesterol
metabolism were evaluated. METHODS AND RESULTS: RT-PCR analysis showed that the
mRNA expression of 38 ABC-transporters detected in livers of C57Bl/6 mice varied greatly.
Although most ABC-transporters were ubiquitously expressed, some members displayed
very restricted expression patterns, eg ABCA6, A8, B1, B8, B10, B11, C3, D2, and G5/G8 …
hepatic expression patterns of ABC-transporters involved in the regulation of cholesterol
metabolism were evaluated. METHODS AND RESULTS: RT-PCR analysis showed that the
mRNA expression of 38 ABC-transporters detected in livers of C57Bl/6 mice varied greatly.
Although most ABC-transporters were ubiquitously expressed, some members displayed
very restricted expression patterns, eg ABCA6, A8, B1, B8, B10, B11, C3, D2, and G5/G8 …
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